Coop and Natalie attempt an actual date, but when they return to Coop's apartment all hell breaks loose. Carter loses Zoe. Sophie needs help working things out with Jeremy, and Diane goes into labor.
After an unexpected development in her personal life, Sophie gets drunk at work on the day of the department gala. Coop rushes to cover for her and in the process encounters the event planner, Natalie.
After a wild night, Coop and Carter both wake up with unwanted company. Coop's colleagues question his odd behavior. Carter tries to settle things with his high school sweetheart.
Coop gives dating advice to a hapless British colleague and relationship advice to Sophie. Carter adopts a ferret. Coop spots Natalie.
Coop's latest hookup, Amy, becomes more than he can handle when she keeps turning up unexpectedly. Carter finds himself in a jam.
Coop makes a last ditch effort to find Natalie using a private detective with questionable methods. Carter and Shadrach do some damage control when they break Coop's television.
Jackson Cooper is a handsome, eternally single psychiatrist living in New York City. Serial dating and workaholic behavior have successfully helped him avoid long-term commitments, until he meets the girl of his dreams. Unfortunately he fails to get her name, number or any other information...