After Whiskers thinks he has been bitten by a frog that can make victims sleep for 50 years and decides to do a lot of things with Brandy including "kiss a preety girl". When Brandy finds out she's the girl to kiss, and the frog that Whiskers had been bitten by has to convince Whiskers the truth.
After being mocked by tortoises, Whiskers decides its high time to challenge the tortoises to a match to tend the tortoise and the hare story end.
Mr. Whiskers finds a book about the Amazon Rain forest, though what he discovers scares him. He decides to steal the lifeboat roof from the tree house and sets off to live in the ocean, though will he succeed in his endeavors?
When Whiskers decides to join Gaspar's wrestling league, he makes Brandy his tag team partner. However, Brandy soon proves to be an excellent wrestler and she adapts the alias of Sammy Crushington.
When Mr. Whiskers finds a bag of shiny rocks, he and Brandy argue over what they should do with it.
When Mr. Whiskers gets a pimple, he thinks he's turning into a monster.
Brandy hypnotizes Whiskers with a pinwheel, and he instantly begins cleaning whenever he hears the word 'Pickle'. Unfortunately, everybody in the jungle starts saying the P word.
Ed and Lola Boa have a crush on each other, so Brandy tries to make the relationship perfect, while Whiskers tries to sabotage the whole thing.
Brandy notices all her ex-boyfriends have new girlfriends, and tries to save face by making up a fictional boyfriend. However, things take a turn for the worse when Mr. Whiskers attempts to actually find the individual that Brandy described.
Whiskers finds Brandy's favorite soft toy from when she was younger, and annoys and embarrasses her by convincing her to play with 'Itty Bitty Kitty' once again. When Brandy gets infuriated, Mr Whiskers gives the toy to Gaspar, though Brandy tries to get it back.
When Mr. Whiskers witnesses the Carnivore Club harassing some nerds at the Mayan Mall, he decides that he wishes to aspire to become a member of their club, as they are some of the coolest individuals in the Amazon. However, Mr. Whiskers isn't cool enough, so he convinces Brandy to train him in order to make him cooler, though will Brandy's lessons actually be enough to make Whiskers cool enough to get into the club?
While at a local lagoon, Mr. Whiskers inadvertently pushes Brandy off of a cliff, though she is rescued by a wild dog as she is falling. Brandy immediately falls in love with Wolfie, though when it turns out that he is less hygienic than Mr. Whiskers, she does what she can to forge him into the perfect boyfriend, though will she be capable of such a feat?
Brandy & Mr. Whiskers is an American animated television series about a pampered yet spunky dog and a hyperactive rabbit who get stuck in the Amazon Rainforest together. The show originally aired from August 2004 to August 2006. It was televised in the United States by Disney Channel.