Emu Hojo, an aspiring doctor, decided to join Cyber Rescue Center as an intern after discovering his Bugster-fighting abilities as Kamen Rider Ex-Aid.
The Bugster Virus, formed from video games, threatens humanity and seeks to turn Bugsters into complete beings. A hospital intern, Emu Hojo, and three other Kamen Riders (Brave, Snipe, and Lazer) must defeat the virus and save humanity.